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Publications

See below some of the most relevant publications that the Liddle Lab has contributed over the years.

The Pancreas

Shahid, R. A., S. R. Vigna, A. C. Layne, J. M.-J. Romac, and R. A. Liddle. Acinar cell production of leukotriene B4 contributes to development of neurogenic pancreatitis in mice. Cellular and Molecular Gastroenterology and Hepatology. 1:75-86, 2015. PMID 25729765.

Chandra, R. and R. A. Liddle. Regulation of Pancreatic Secretion. Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2015.38, 2015.

Kanju P., Y. Chen, W. Lee, M. Yeo, S. H. Lee, J. Romac, R. Shahid, P. Fan, D. Gooden, S. A. Simon, I. Spasojevic, R. A Mook, R. A. Liddle, F. Guilak, and W. B. Liedtke. Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Scientific Reports. 6:26894, DOI: 10.1038/srep26894, 2016. PMID: 27247148.

Liddle, R. A. "Location, location, location"... It is important in pancreatitis, too. Cellular and Molecular Gastroenterology and Hepatology. 3:6-7, 2016. PMID: 28174753.

Romac, J. M.-J., R. A. Shahid, S. M. Swain, S. R. Vigna, and R. A. Liddle. Piezo1 is a mechanically activated ion channel and mediates pressure-induced pancreatitis. Nature Communications. 9:1715, 2018. DOI: 10.1038/s41467-018-04194-9. PMID: 29712913.

Swain, S. M. and R. A. Liddle. Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to so shear stress. Journal of Biological Chemistry. 296:100171, 2020. PMID: 33298523.

Vigna, S. R. and R. A. Liddle. Calcium in pancreatitis... immune cells, too? Function. 2021 2(1):zqaa030. DOI: 10.1093/function/zqaa030. PMID: 33345191.

Swain, S. M., J. M.-J. Romac, R. A. Shahid, S. J. Pandol, W. Liedtke, S. R. Vigna, and R. A. Liddle. TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. Journal of Clinical Investigation. 130:2527-2541, 2020. DOI: 10.1172/JCI134111. PMID: 31999644.

Farooq, A., C. M. Richman, S. M. Swain, S. R. Vigna and R. A. Liddle. The role of phosphate in alcohol-induced experimental pancreatitis. Gastroenterology. 161:982-995, 2021. PMID: 34051238.

A. Farooq, L. Hernandez, S. M. Swain, R. A. Shahid, J. M.-J. Romac, S. R. Vigna, and R. A. Liddle. Initiation and severity of experimental pancreatitis are modified by phosphate. American Journal of Physiology. 322:G561-G570, 2022. PMID:35293263.

S. M. Swain, J. M. Romac, S. R. Vigna and R. A. Liddle. Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis. JCI Insight. 7:e158288, 2022. PMID:35451372.

Sandip M. Swain and Rodger A. Liddle. Mechanosensing Piezo channels in gastrointestinal disorders. J Clin Invest. 2023;133(19):e171955.

Enteroendocrine Cells and the Gut Connectome

Bohórquez, D. V., L. A. Samsa, A. Roholt, S. Meticetty, R. Chandra, and R. A. Liddle. An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. PLoS One. 9:e89881, 2014. PMID 24587096.

Bohórquez, D. V., R. A. Shahid, A. Erdmann, A. M. Kreger, Y. Wang, N. Calakos, F. Wang, and R. A. Liddle. Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. Journal of Clinical Investigation. 125:782-786, 2015. PMID 25555217.

Bohórquez, D. V., F. Haque, S. Medicetty, and R. A. Liddle. Correlative confocal and 3D electron microscopy of a specific sensory cell. Journal of Visualized Experiments. (101), e52918, DOI:10.3791/52918 (2015). PMID: 26273796.

Bohórquez, D. V. and R. A. Liddle. The gut connectome: making sense of what you eat. Journal of Clinical Investigation. 125:888-890, 2015. PMID: 25729849.

Ye, L. and R. A. Liddle. Gastrointestinal hormones and the gut connectome. Current Opinion in Endocrine and Metabolic Research. 24:9-14, 2017. PMID: 27820704.

Chandra, R., A. Hiniker, Y. M. Kuo, R. L. Nussbaum, and R. A. Liddle. a-Synuclein in gut endocrine cells and its implications for Parkinson's disease. JCI Insight. 2: pii: 92295. DOI: 10.1172/jci.insight.92295. 2017. PMID: 28614796.

Liddle, R. A. Interactions of gut endocrine cells with epithelium and neurons. Comprehensive Physiology. 8:1019-1030, 2018. PMID:29978902.

Liddle, R. A. Parkinson's disease from the gut. Brain Research. DOI: 10.1016/j.brainres.2018.01.010, 2018. PMID: 29360467.

Chandra, R. and R. A. Liddle. Cholecystokinin. Pancreapedia: Exocrine Pancreas Knowledge Base. DOI: 10.3998/panc.2018.18. 2018.

Liddle, R.A. Neuropods. Cellular and Molecular Gastroenterology and Hepatology. 7:739-747, 2019. PMID:30710726.

Ye, L., O. Mueller, J. Bagwell, M. Bagnat, R. A. Liddle, and J. F. Rawls. High-fat diet induces microbiota-dependent silencing of enteroendocrine cells. eLife. 2019; e48479 DOI: 10.7554/eLife.48479.

Ye L., M. Bae, C. D. Cassilly, S. V. Jabba, D. W. Thorpe, A. M. Martin, H.-Y. Lu, J. Wang, J. D. Thompson, C. R. Lickwar, K. D. Poss, D. J. Damien, S.-E. Jordt, J. Clardy, R. A. Liddle, and J. F. Rawls. Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host & Microbe 2021. 29:179-196.e9. PMID: 33352109.

Sokratian A, J. Ziaee, K. Kelly, A. Chang, N. Bryant, S. Wang, E. Xu, J. Y. Li, S. H. Wang, J. Ervin, S. M. Swain, R. A. Liddle, and A. B. West. Heterogeneity in a-synuclein fibril activity correlates to disease phenotypes in Lewy antibody dementia. Acta Neuropathologica. 141:547-564, 2021. PMID: 33641009.

Chandra R, DK Aryal, JD Douros, R Shahid, SJ Davis, JE Campbell, O Ilkayeya, PJ White, R Rodriguez CB Newgard, WC Wetsel, and RA Liddle. Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia. PLoS One, 2022 Jun 24;17(6):e0270329, PMID:35749484

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